Dermatophytic defensin with antiinfective potential
نویسندگان
چکیده
منابع مشابه
Dermatophytic defensin with antiinfective potential.
Fungi are a newly emerging source of peptide antibiotics with therapeutic potential. Here, we report 17 new fungal defensin-like peptide (fDLP) genes and the detailed characterization of a corresponding synthetic fDLP (micasin) from a dermatophyte in terms of its structure, activity and therapeutic potential. NMR analysis showed that synthetic micasin adopts a "hallmark" cysteine-stabilized α-h...
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The treatment of onychomycosis is a difficult and long-standing course because of the relatively low success and high recurrence rates and the necessity of laboratory monitoring for the traditional oral antifungal agents. The introduction of newer systemic antifungal drugs such as triazoles (itraconazole and fluconazole) and allylamines (terbinafine) offer an increased cure rate, a broader spec...
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The unfavorable effects of neonatal immunodeficiency are limited by some naturally occurring compensatory mechanisms, such as the introduction of protective and immunological components of human milk in the infant. Breast-feeding maintains the maternal-fetal immunological link after birth, may favor the transmission of immunocompetence from the mother to her infant, and is considered an importa...
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JOHANSON, R. 1953 New specific reagent for keto-sugars. Nature, 172, 956-957. KOEHLER, L. H. 1952 Differentiation of carbohydrates by anthrone reaction rate and color intensity. Anal. Chem., 24, 1576-1579. PALMER, A. 1951 The specific determination and detection of glucose as a probable constituent radical of certain fructosans by means of notatin. Biochem. J., 48, 389-394. SHAFFER, P. A., AND ...
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Out of 410 clinically diagnosed cases of superficial mycoses encountered during 1985 - 87, direct KOH mounts were positive in 250 (62.19%) cases and the cultures were positive in 123 (30.00%) cases. The organisms isolated included Trichophyton rubrum (36.58%). T. simii (32.52%), T.mentagrophytes (12.19%), C.tropicum (8.13%), Microsporum gypseum (6.50%), Epidermophyton floccossum (2.43%), T. vio...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2012
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1201263109